Generalized plasma skimming model for cells and drug carriers in the microvasculature.
نویسندگان
چکیده
In microvascular transport, where both blood and drug carriers are involved, plasma skimming has a key role on changing hematocrit level and drug carrier concentration in capillary beds after continuous vessel bifurcation in the microvasculature. While there have been numerous studies on modeling the plasma skimming of blood, previous works lacked in consideration of its interaction with drug carriers. In this paper, a generalized plasma skimming model is suggested to predict the redistributions of both the cells and drug carriers at each bifurcation. In order to examine its applicability, this new model was applied on a single bifurcation system to predict the redistribution of red blood cells and drug carriers. Furthermore, this model was tested at microvascular network level under different plasma skimming conditions for predicting the concentration of drug carriers. Based on these results, the applicability of this generalized plasma skimming model is fully discussed and future works along with the model's limitations are summarized.
منابع مشابه
Effect of fractional blood flow on plasma skimming in the microvasculature.
Although redistribution of red blood cells at bifurcated vessels is highly dependent on flow rate, it is still challenging to quantitatively express the dependence of flow rate in plasma skimming due to nonlinear cellular interactions. We suggest a plasma skimming model that can involve the effect of fractional blood flow at each bifurcation point. To validate the model, it is compared with in ...
متن کاملCell and nanoparticle transport in tumour microvasculature: the role of size, shape and surface functionality of nanoparticles.
Through nanomedicine, game-changing methods are emerging to deliver drug molecules directly to diseased areas. One of the most promising of these is the targeted delivery of drugs and imaging agents via drug carrier-based platforms. Such drug delivery systems can now be synthesized from a wide range of different materials, made in a number of different shapes, and coated with an array of differ...
متن کاملStatistical Modeling for Oblique Collision of Nano and Micro Droplets in Plasma Spray Processes
Spreading and coating of nano and micro droplets on solid surfaces is important in a wide variety of applications including plasma spray coating, ink jet printing, DNA synthesis and etc. In spraying processes, most of droplets collide obliquely to the surface. The purpose of this article is to study the distribution of nano and micro droplets spreading when droplets impact at an oblique a...
متن کاملNew Platforms For Drug Screening And Toxicology: Necessity Or Need?
The liver is the largest internal organ in the human body that is responsible for more than 500 vital functions, including biosynthesis of major plasma proteins, immunity against infectious pathogens, balancing energy metabolism and xenobiotics biotransformation (1). One of the main functions of the liver is an important role in drug metabolism (2). Since developing new drug compounds into mark...
متن کاملIn-vitro study of Ketoprofen release from synthesized silica aerogels (as drug carriers) and evaluation of mathematical kinetic release models
Silica aerogels are porous and extremely lightweight nano-materials shows interesting properties. These materials, because of biocompatibility, non-harmful to the body and special physical characteristics such as large surface area and low density have great potential for use in a drug delivery system (DDS). The focus of this study is the evaluation of the effects of silica aerogels on improvin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Biomechanics and modeling in mechanobiology
دوره 16 2 شماره
صفحات -
تاریخ انتشار 2017